皮肤细胞变身血细胞

作者:未知 来源:未知 2013-03-30

Using viral gene insertion and regulatory proteins, researchers turned adult human skin cells directly into adult human blood cells, without first returning them to a fully pluripotent state. Steve Mirsky reports
利用病毒基因插入和调节蛋白,科学家们可以不用把人类皮肤细胞先转变成原来的多能态细胞,就直接转化为成年人的血细胞。

One of the dreams of biomedical scientists is to be able to transform adult cells into other kinds of cells. And thus avoid some of the ethical concerns of working with embryonic stem cells. Now a research team from McMaster University in Ontario has announced that they’ve been able to transform human skin cells into blood cells. The work was published online on November 7th by the journal Nature. [Eva Szabo et al., "Direct conversion of human fibroblasts to multilineage blood progenitors"]
面对使用胚胎干细胞转化所需要面对的道德问题。现在,来自安大略省马克马斯特大学的科研团队宣称,他们已经能够把人类皮肤细胞转变成血细胞了,这项研究结果发表在了11月7日的《自然》杂志上。
Other research in this area has required that cells of one type first be returned to a more generally undifferentiated stem cell state, which can introduce fresh problems. Once there, the cell is then turned into the type of tissue the researchers seek. But in this case, the scientists avoided the middleman cell. The skin was changed directly into what appears to be functional adult human blood cells. The technique involves gene insertion by a virus vector and exposure to numerous regulatory proteins.
该研究领域的其他技术都需要先将一种类型的细胞变回到普遍未经分化的干细胞状态,而干细胞才能发生分化。一旦变回了干细胞状态,细胞就能分化为任意一种科学家想要的细胞。但是采用这项技术的话,科学家不需要中间过程,可以直接把皮肤细胞变成任意一种具有功能的成年人血细胞。这项技术利用了一个病毒载体的基因插入,以及大量参与调控的蛋白质。

The cells have not been tested in humans to see if they’re truly indistinguishable from the home-grown kind. But the research is another step in the effort to create needed cell types from easily available ones.
转变出来的细胞还没有进行人体测试,以检测它们是否与人体自然产生的血细胞一样。但是,开展研究的目的就是要提出一种可以方便使用细胞的方法。

词汇解释

1. pluripotent adj. [生]多能性的

2. embryonic a.胚胎的,萌芽期的

3. fibroblast n. 纤维原细胞

4. progenitor n.祖先

5. undifferentiated adj. 无差别的, 未显出差别的, 一致的

6. stem cell 干细胞

7. indistinguishable adj. 不能区别的, 难区分的, 不易觉察的

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